TOUR GUIDE

  1. A click on Human Genome Sequencing Projects will take you to a table summarizing current sequencing activities in the YMGC.

  2. Go to Chromosome 4 mapping and sequencing project. Click the red box and it will take you to the physical map of the 4q22-24 region.

  3. Current mapping projects are divided into four sections: IC (D4S1578-D4S421), IT (WI6987-D4S2790), IIC (D4S1504-D4S1578), and IIT (D4S2790-D4S1564). Genome sequencing efferts were focused initially on two clusters: MKDBC and FNOPQ.

  4. Similarly, click the red box in Chromosome 16 mapping and sequencing project. From there, enter the 16q22 region.

  5. In the chromosome 4q22-24 and chromosome 16q22 BAC contig maps, click any of the color-coded boxes and see the status report and sequence information for each BAC clone.

  6. In each project, available raw data can be retrieved in simple text or Zip file. Just click the color-coded box in the page. Black box indicates ends of BAC and red triangle points to the overlapping clones.

  7. In finished BAC projects, DNA sequences were analyzed to identify genes, repeats, and variations (polymorphisms, mutations).

  8. Information of ESTs of the chromosome 4 HCC critical region can be found by clicking the green (G3 map) or the blue (GB4 map) button. A link to NCBI server will be activated to view the GeneMap'99.

  9. ESTs of the chromosome 16 HCC critical region is available by clicking anywhere along the genetic map to connect to the GeneMap'99. A hand sign indicates the position of the reference interval being reached.

  10. We are sequencing the mouse syntenic region corresponding to the chromosome 4 HCC tumor suppressor gene critical region. Initial effort is directed to the Adh gene complex. Current status of mouse genome sequencing projects and progress of individual clones are presented as for the human genome sequencing projects.
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